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Progress on molecular biomarkers and classification of malignant gliomas
null
《医学前沿(英文)》 2013年 第7卷 第2期 页码 150-156 doi: 10.1007/s11684-013-0267-1
Gliomas are the most common primary intracranial tumors in adults. Anaplastic gliomas (WHO grade III) and glioblastomas (WHO grade IV) represent the major groups of malignant gliomas in the brain. Several diagnostic, predictive, and prognostic biomarkers for malignant gliomas have been reported over the last few decades, and these markers have made great contributions to the accuracy of diagnosis, therapeutic decision making, and prognosis of patients. However, heterogeneity in patient outcomes may still be observed, which highlights the insufficiency of a classification system based purely on histopathology. Great efforts have been made to incorporate new information about the molecular landscape of gliomas into novel classifications that may potentially guide treatment. In this review, we summarize three distinctive biomarkers, three most commonly altered pathways, and three classifications based on microarray data in malignant gliomas.
关键词: malignant glioma molecular biomarker IDH1 MGMT molecular classification
Human microbiome and prostate cancer development: current insights into the prevention and treatment
Solmaz Ohadian Moghadam, Seyed Ali Momeni
《医学前沿(英文)》 2021年 第15卷 第1期 页码 11-32 doi: 10.1007/s11684-019-0731-7
关键词: microbiome prostate cancer prevention treatment molecular pathological epidemiology (MPE) biomarker
Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis
《医学前沿(英文)》 2022年 第16卷 第2期 页码 216-226 doi: 10.1007/s11684-022-0920-7
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
《环境科学与工程前沿(英文)》 2014年 第8卷 第1期 页码 99-105 doi: 10.1007/s11783-013-0490-7
Plasma transthyretin is a nutritional biomarker in human morbidities
《医学前沿(英文)》 2022年 第16卷 第4期 页码 540-550 doi: 10.1007/s11684-022-0940-3
关键词: lean body mass nutritional status transthyretin malnutrition inflammation amyloidosis
Biosensor-based assay of exosome biomarker for early diagnosis of cancer
《医学前沿(英文)》 2022年 第16卷 第2期 页码 157-175 doi: 10.1007/s11684-021-0884-z
Changlin Cao, Jingxian Gu, Jingyao Zhang
《医学前沿(英文)》 2017年 第11卷 第2期 页码 169-177 doi: 10.1007/s11684-017-0505-z
关键词: soluble triggering receptor expressed on myeloid cells-1 infectious diseases diagnosis and prognosis biomarker
《医学前沿(英文)》 2022年 第16卷 第5期 页码 723-735 doi: 10.1007/s11684-021-0905-y
关键词: amyotrophic lateral sclerosis coronin-1a autophagy pathogenesis
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 278-285 doi: 10.1007/s11684-016-0453-z
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. We aimed to find novel molecules as potential biomarkers for the early diagnosis of CRC. A serum-free conditioned medium was successfully collected from three pairs of CRC tissue and adjacent normal tissue. iTRAQ-based quantitative proteomic analysis was applied to compare the differences in secretome between primary CRC mucosa and adjacent normal mucosa. A total of 145 kinds of proteins were identified. Of these proteins, 29 were significantly different between CRC and normal tissue. Tropomyosin 2 β (TPM2) exhibited the most significant differences; as such, this protein was selected for further validation. Quantitative real-time PCR indicated that the mRNA expression of TPM2 significantly decreased in the CRC tissue compared with the paired adjacent normal tissue. Immunohistochemical analysis also confirmed that TPM2 was barely detected at protein levels in the CRC tissue. In summary, this study revealed potential molecules for future biomarker applications and provided an efficient approach for the differential analysis of cancer-associated secretome. TPM2 may be valuable for the early diagnosis of CRC.
Sepsis biomarkers: an omics perspective
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《医学前沿(英文)》 2014年 第8卷 第1期 页码 58-67 doi: 10.1007/s11684-014-0318-2
Sepsis is a common cause of death in hospitalized patients worldwide. The early detection of sepsis remains a great challenge for clinicians, and delayed diagnosis frequently undermines treatment efforts, thereby contributing to high mortality. Omics technologies allow high-throughput screening of sepsis biomarkers. This review describes currently available and novel sepsis biomarkers in the context of genomics, transcriptomics, proteomics, and metabolomics. The combination of these technologies can help refine the diagnosis of sepsis. This review paper serves as a reference for future studies that employ an integrated, multi-omics approach to disease identification.
关键词: sepsis biomarker genomics transcriptomics proteomics metabolomics
Special issue on “Molecular Sensors and Molecular Logic Gates”
Luling Wu , Tony D. James
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 1-3 doi: 10.1007/s11705-021-2134-y
《化学科学与工程前沿(英文)》 2022年 第16卷 第2期 页码 168-182 doi: 10.1007/s11705-021-2056-8
关键词: computer-aided molecular design bio-oil additives molecular signature descriptor
Molecular classification and molecular targeted therapy of cancer
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 147-149 doi: 10.1007/s11684-013-0274-2
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
《环境科学与工程前沿(英文)》 2016年 第10卷 第6期 doi: 10.1007/s11783-016-0880-8
关键词: miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha
《医学前沿(英文)》 2022年 第16卷 第3期 页码 378-388 doi: 10.1007/s11684-021-0840-y
关键词: severe Mycoplasma pneumoniae pneumonia children proteomics Fc fragment of the IgG-binding protein mechanistic target of rapamycin kinase inhibitor
标题 作者 时间 类型 操作
Human microbiome and prostate cancer development: current insights into the prevention and treatment
Solmaz Ohadian Moghadam, Seyed Ali Momeni
期刊论文
MiRNA-451 is a potential biomarker for estrogenicity in mouse uterus
Lingyan HOU, Yun LU, Ying LI, Li LI
期刊论文
Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis
Changlin Cao, Jingxian Gu, Jingyao Zhang
期刊论文
Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker
期刊论文
iTRAQ-based quantitative analysis of cancer-derived secretory proteome reveals TPM2 as a potential diagnostic biomarker
null
期刊论文
Design of bio-oil additives via molecular signature descriptors using a multi-stage computer-aided molecular
期刊论文
U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen
Rui Duan, Yun Lu, Lingyan Hou, Lina Du, Lequn Sun, Xingfan Tang
期刊论文